Ender, A., Grafl, N., Kolberg, T., Findeiß, S., Stadler, P. F., and Mörl, M. (2022) Synthetic Riboswitches for the Analysis of tRNA Processing by eukaryotic RNase P Enzymes. RNA, doi: 10.1261/rna.078814.121Abstract 
Ender, A., Stadler, P. F., Mörl, M., and Findeiß, S. (2022) RNA Design Principles for Riboswitches that Regulate RNase P-Mediated tRNA Processing. Methods Mol. Biol., in press.


de Wijn, R., Rollet, K., Ernst, F.G.M., Wellner, K., Betat, H., Mörl, M., Sauter, C. (2021) CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus. Comput. Struct. Biotechnol. J. 19, 5845-5855. doi: 10.1016/j.csbj.2021.10.018 Abstract
Hoffmann, A., Erber, L., Betat, H., Stadler, P. F., Mörl, M, and Fallmann, J. (2021) Changes of the tRNA modification pattern during the development of Dictyostelium discoideum. ncRNA 7(2), 32. doi: 10.3390/ncrna7020032Abstract
Erber, L., Betat, H., and Mörl, M. (2021) CCA Addition gone wild: Unusual Occurrence and Phylogeny of four different tRNA Nucleotidyltransferases in Acanthamoeba castellanii. Mol. Biol. Evol. 38(3), 1006-1017. doi: 10.1093/molbev/msaa270Abstract

Günzel, C., Kühnl, F., Arnold, K., Findeiß, S., Weinberg, C., Stadler, P. F., and Mörl, M. (2021) Beyond Plug and Pray: Context Sensitivity and in silico Design of Artificial Neomycin Riboswitches. RNA Biology 18(4), 457-467. doi: 10.1080/15476286.2020.1816336
de Wijn, R., Rollet, K., Olieric, V., Hennig, O., Thome, N., Noûs, C., Paulus, C., Lorber, B., Betat, H., Mörl, M., Sauter, C. (2021) Crystallization and structural determination of an enzyme:substrate complex by serial 2 crystallography in a versatile microfluidic chip. J. Vis. Exp. 169, doi: 10.3791/61972Abstract
Ender, A., Etzel, M., Hammer, S., Findeiß, S., Stadler, P. F., and Mörl, M. (2021) Ligand-Dependent tRNA Processing by a Rationally Designed RNase P Riboswitch. Nucleic Acids Res. 49(3), 1784–1800, doi: 10.1093/nar/gkaa1282



Hennig, O., Philipp, S., Bonin, S., Rollet, K., Kolberg, T., Jühling, T., Betat, H., Sauter, C., and Mörl, M. (2020) Adaptation of the Romanomermis culicivorax CCA-adding enzyme to miniaturized armless tRNA substrates. Int. J. Mol. Sci., 2020, 21(23), 9047. doi: 10.3390/ijms21239047
Erber, L., Hoffmann, A., Fallmann, J., Hagedorn, M., Hammann, C., Stadler, P. F., Betat, H., Prohaska, S., and Mörl, M. (2020) Unusual occurrence of two bona-fide CCA-adding enzymes in Dictyostelium discoideum. Int. J. Mol. Sci. 2020, 21 (15), 5210. doi: 10.3390/ijms21155210Abstract
De Wijn, R., Rollet, K., Engilberge, S., McEwen, A., Hennig, O., Betat, H., Mörl, M., Maury, O., Girard, E., Benas, P., Lorber, B., and Sauter. C. (2020) Monitoring the production of high diffraction-quality crystals of two enzymes in real time using in situ dynamic light scattering. Crystals 10, 65. doi:10.3390/cryst10020065Abstract
Erber, L., Franz, P., Betat, H., Prohaska, S., and Mörl, M. (2020) Divergent evolution of eukaryotic CC- and A-adding enzymes. Int. J. Mol. Sci. 2020, 21(2), 462, doi: 10.3390/ijms21020462       Abstract        
Erber, L., Hoffmann, A., Fallmann, J., Betat, H., Stadler, P.F., and Mörl, M. (2020) LOTTE-seq (Long hairpin oligonucleotide based tRNA high-throughput sequencing): Specific selection of tRNAs with 3’-CCA end for high-throughput sequencing. RNA Biology 17 (1), 23-32. doi: 10.1080/15476286.2019.1664250Abstract


Kirsch, R., Olzog, V.J., Bonin, S., Weinberg, C.E., Betat, H., Stadler, P.F., and Mörl, M. (2019) A streamlined Protocol for the Detection of mRNA-sRNA Interactions using AMT-Crosslinking in vitro. BioTechniques 67 (4), 178-183. doi: 10.2144/btn-2019-0047
Hammer, S., Günzel, C., Mörl, M. and Findeiß, S. (2019) Evolving Methods for rational de novo Design of functional RNA Molecules. Methods 161, 54-63. doi: 10.1016/j.ymeth.2019.04.022Abstract
Pöhler, M.-T., Roach, T.M., Betat, H., Jackman, J.E. and Mörl, M. (2019)  A Temporal Order in 5'- and 3'- Processing of Eukaryotic tRNAHis. Int. J. Mol. Sci., 20(6), pii: E1384. doi: 10.3390/ijms20061384.Abstract
de Wijn R., Hennig, O., Roche, J., Engilberge, S., Rollet, K., Fernandez-Millan, P., Brillet, K., Betat, H., Mörl, M., Roussel, A., Girard, E., Mueller-Dieckmann, C., Fox, G.C., Oliéric, V., Gavira, J.-A., Lorber, B. and Sauter, C. (2019) A simple and versatile microfluidic Device for efficient Biomacromolecule Crystallization and structural Analysis by serial Crystallography. IUCrJ,6(3), 454-464. doi: 10.1107/S2052252519003622 Abstract
Wellner, K., Pöhler, M.-T., Betat, H., and Mörl, M. (2019) Dual Expression of CCA-adding Enzyme and RNase T in Escherichia coli generates a distinct cca Growth Phenotype with diverse Applications. Nucleic Acids Res. 47(7), 3631-3639. doi: 10.1093/nar/gkz133 Abstract
Wellner, K. and Mörl, M. (2019) Post-transcriptional regulation of tRNA pools to govern the Central Dogma – a Perspective. Biochemistry 58(5), 299-304. doi: 10.1021/acs.biochem.8b00862Abstract


Ernst, F.G.M., Erber, L., Sammler, J., Jühling, F., Betat, H. and Mörl, M. (2018) Cold Adaptation of tRNA Nucleotidyltransferases: A Tradeoff in Activity, Stability and Fidelity. RNA Biology, 15, 144-155. doi: 10.1080/15476286.2017.1391445 Abstract
Serfling, R., Lorenz, C., Etzel, M., Schicht, G., Böttke, T., Mörl, M. and Coin, I. (2018) Designer tRNAs for efficient Incorporation of non-canonical Amino Acids by the Pyrrolysine System in mammalian Cells. Nucleic Acids Res., 46, 1, 1-10 (breakthrough article). doi: 10.1093/nar/gkx1156
Wellner, K., Betat, H. and Mörl, M. (2018) A tRNA's fate is decided at its 3' end: Collaborative actions of CCA adding enzyme and RNases involved in tRNA processing and degradation. Biochim. Biophys. Acta 1861, 433-441. doi: 10.1016/j.bbagrm.2018.01.012Abstract
Wellner, K., Czech, A., Ignatova, Z., Betat, H. and Mörl, M. (2018) Examining tRNA 3'-ends in Escherichia coli: teamwork between CCA-adding enzyme, RNase T, and RNase R. RNA 24,361-370. doi: 10.1261/rna.064436.117Abstract
Hoffmann, A., Fallmann, J., Vilardo, E., Mörl, M., Stadler, P.F. and Amman, F. (2018) Accurate Mapping of tRNA Reads. Bioinfomatics 34, No. 7, 1116-1124. doi: 10.1093/bioinfomatics/bty118Abstract
Jühling, T., Durchardt-Ferner, E., Bonin, S., Wöhnert, J., Pütz, J., Florentz, C., Betat, H., Sauter, C. and Mörl, M. (2018) Small but large enough: structural properties of armless mitochondrial tRNAs from the nematode Romanomermis culicivorax. Nucleic Acids Res. 46, 17, 9170-9180. doi: 10.1093/nar/gky593Abstract
de Wijn, R., Hennig, O., Ernst, F. G. M., Lorber, B., Betat, H., Mörl, M. and Sauter, C. (2018) Combining crystallogenesis methods to produce diffraction-quality crystals of a psychrophilic tRNA maturating enzyme. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 74, 747-753. doi: 10.1107/S2053230X18014590Abstract


Etzel, M. and Mörl, M. (2017) Synthetic Riboswitches – from Plug and Pray towards Plug and Play. Biochemistry, 56, No. 9, 1181-1198. doi: 10.1021/acs.biochem.6b01218


Lorenz, C., Lünse, C.E. and Mörl, M. (2017) tRNA Modifications: Impact on Structure and thermal Adaptation. Biomolecules, 7, No. 2, pii: E35. doi: 10.3390/biom7020035


Domin, G., Findeiß, S., Wachsmuth, M., Will, S., Stadler, P.F. and Mörl, M. (2017) Applicability of a computational Design Approach for synthetic Riboswitches. Nucleic Acids Res. 45, No. 7, 4108-4119. doi: 10.1093/nar/gkw1267Abstract
Findeiß, S., Etzel, M., Will, S., Mörl, M. and Stadler, P.F. (2017) Design of artificial Riboswitches as Biosensors. Sensors 17, 1990. doi: 10.3390/s17091990Abstract


Franz, P., Betat, H. and Mörl, M. (2016) Genotyping bacterial and fungal Pathogens using Sequence Variation in the Gene for the CCA-adding Enzyme. BMC Microbiology 16 (1), 47. Erratum: BMC Microbiology 16 (1), 219. doi: 10.1186/s12866-016-0670-2Abstract


Betat, H. and Mörl, M. (2015) The CCA-adding Enzyme: a central Scrutinizer in tRNA Quality Control. BioEssays 37, 975-982. doi: 10.1002/bies.201500043


Betat, H., Mede, T., Tretbar, S., Steiner, L., Stadler, P.F., Mörl, M. and Prohaska, S.J. (2015) The Ancestor of modern Holozoa acquired the CCA-adding Enzyme from Alpha-proteobacteria by horizontal Gene Transfer. Nucleic Acids Res. 43, No. 14, 6739-6746. doi: 10.1093/nar/gkv631Abstract
Wende, S., Götze, O., Betat, H. and Mörl, M. (2015) The identity of the discriminator base has an impact on CCA addition. Nucleic Acids Res. 43, No. 11, 5617-5629. doi: 10.1093/nar/gkv471Abstract
Wachsmuth, M., Domin, G.,  Lorenz, R., Serfling, R., Findeiß, S., Stadler, P.F. and Mörl, M. (2015) Design criteria for synthetic riboswitches acting on transcription. RNA Biol. 12, No. 2, 221-231. doi: 10.1080/15476286.2015.1017235Abstract
Ernst, F.G.M., Rickert, C., Bluschke, A., Betat, H., Steinhoff, H.J. and Mörl, M. (2015) Domain movements during CCA Addition: a new Function for Motif C in the catalytic Core of the human tRNA Nucleotidyltransferases. RNA Biol., 12, 435-446. doi: 10.1080/15476286.2015.1018502Abstract
Findeiß, S., Wachsmuth, M., Mörl, M. and Stadler, P.F. (2015) Design of Transcription regulating Riboswitches. Method Enzymol. 550, 1-22. doi: 10.1016/bs.mie.2014.10.029Abstract


Betat, H., Long, Y.,  Jackmann, J.E. and Mörl, M.  (2014) From End to End: tRNA Editing at 5'- and 3'- terminal Positions. Int. J. Mol. Sci. 15, 23975-23998. doi: 10.3390/ijms151223975


Wende, S., Platzer, E.G., Jühling, F., Pütz, J., Florentz, C., Stadler, P.F. and Mörl, M. (2014) Biological Evidence for the World’s smallest tRNAs. Biochimie 100, 151-158. doi: 10.1016/j.biochi.2013.07.034Abstract


Czech, A., Wende, S., Mörl, M., Pan, T. and Ignatova, Z. (2013) Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress. PLoS Genet 9(8): e1003767. doi: 10.1371/journal.pgen.1003767


Doose, G., Alexis, M., Kirsch, R., Findeiß, S., Langenberger, D., Machné, R., Mörl, M., Hoffmann, S. and Stadler, P.F. (2013) Mapping the RNA-Seq Trash Bin: Unusual Transcripts in prokaryotic Transcriptome Sequencing Data. RNA Biol. 10, No. 7, 78-84. doi: 10.4161/rna.24972Abstract
Wachsmuth, M., Findeiß, S., Weissheimer, N., Stadler, P. F. and Mörl, M. (2013) De novo Design of a synthetic Riboswitch that regulates Transcription Termination. Nucleic Acids Res. 41, No. 4, 2541-2551 (featured article). doi: 10.1093/nar/gks1330Abstract


Helm, M., Mörl, M., Stadler, P. F. and Hoffmann, S. (2012) Die nächste Generation der RNA Revolution – Deep Sequencing. Nachrichten aus der Chemie 3, 300.


Dickinson, H., Tretbar, S., Betat, H. and Mörl, M. (2012)  The TRAMP complex shows tRNA Editing Activity in S. cerevisiae. Mol. Biol. Evol. 29, No. 5, 1451-1459. doi: 10.1093/molbev/msr312Abstract
Wolf, J., Obermaier-Kusser, B., Jacobs, M., Milles, C., Mörl, M., von Pein, H.D. and Bauer, M. F. (2012) A new mitochondrial Point Mutation in the transfer RNALys Gene associated with progressive external Ophthalmoplegia with impaired Respiratory Regulation. J. Neurol. Sci. 316, 108-111. doi: 10.1016/j.jns.2012.01.013Abstract


Betat, H. and Mörl, M. (2011) CCA-addierende Enzyme: Hochspezifische RNA-Polymerasen mit ungewöhnlichen Eigenschaften. Biospektrum 05/2011, 510-513.


Tretbar, S., Neuenfeldt, A., Betat, H. and Mörl, M. (2011) An inhibitory C-terminal Region dictates the Specificity of A-adding Enzymes. Proc. Natl. Acad. Sci. USA 108, No. 52, 21040-21045. doi: 10.1073/pnas.1116117108Abstract
Schütze, T., Wilhelm, B., Greiner, N., Braun, H., Peter, F., Mörl, M., Erdmann, V. A., Lehrach, H., Konthur, Z., Menger, M., Arndt, P. F. and Glökler, J. (2011) Probing the SELEX Process with next-generation Sequencing. PLoS One 6, No. 12, e29604. doi: 10.1371/journal.pone.0029604Abstract


Hoffmeier, A., Betat, H., Bluschke, A., Günther, R., Junghanns, S., Hofmann, H.-J. and Mörl, M. (2010) Unusual Evolution of a catalytic Core Element in CCA-adding Enzymes. Nucleic Acids Res. 38, No. 13, 4436-4447 doi: 10.1093/nar/gkq176


Betat, H., Rammelt, C. and Mörl, M. (2010) tRNA Nucleotidyltransferases: Ancient Catalysts with an unusual Mechanism of Polymerization. Cell. Mol. Life Sci. 67 No. 9, 1447-1463 doi: 10.1007/s00018-010-0271-4Abstract
Vörtler, S. and Mörl, M. (2010) tRNA Nucleotidyltransferases: Highly unusual RNA Polymerases with vital Functions. FEBS Lett. 584(2), 297-302. doi: 10.1016/j.febslet.2009.10.078Abstract
Betat, H. and Mörl, M. (2010) tRNAs: Neue Funktionen für alte Bekannte. Labor & More 3.10, 22-25.


Butter, F., Scheibe, M., Mörl, M. and Mann, M. (2009) Unbiased RNA-Protein Interaction Screen by quantitative Proteomics. Proc. Natl. Acad. Sci. USA, 106, 10626-10631. doi: 10.1073/pnas.0812099106


Jühling, F., Mörl, M., Hartmann, R., Sprinzl, M., Stadler, P. F. and Pütz, J. (2009) tRNAdb 2009: Compilation of tRNA Sequences and tRNA Genes. Nucleic Acids Res. 37, D159-D162. doi: 10.1093/nar/gkn772Abstract


Just, A., Butter, F., Trenkmann, M., Heitkam, T., Mörl, M. and Betat, H. (2008) A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme. Nucleic Acids Res. 36, No. 16, 5212-5220. doi: 10.1093/nar/gkn494


Neuenfeldt, A., Just, A., Betat, H. and Mörl, M. (2008) Evolution of tRNA Nucleotidyltransferases: A Small Deletion generated CC-Adding Enzymes. Proc. Natl. Acad. Sci. USA 105, No.23, 7953-7958. doi: 10.1073/pnas.0801971105 Abstract
Lizano-Gonzales, E., Scheibe, M., Rammelt, C., Betat, H. and Mörl, M. (2008) A comparative Analysis of CCA-Adding Enzymes from Human and E. coli: Differences in CCA Addition and tRNA 3’-End Repair. Biochimie 90, 762-772. doi: 10.1016/j.biochi.2007.12.007Abstract
Hartmann, R. K., Mörl, M. and Willkomm, D. K. (2008) Contribution to the chapter "Ribozymes". Nucleic Acids from A to Z, VCH Wiley, 22-35


Scheibe, M., Bonin, S., Hajnsdorf, E., Betat, H. and Mörl, M. (2007) Hfq stimulates the Activity of the CCA-adding Enzyme. BMC Mol. Biol. 8, 92 doi: 10.1186/1471-2199-8-92


Lizano-Gonzales, E., Schuster, J., Müller, M., Kelso, J. and Mörl, M. (2007) A Splice Variant of the human CCA adding Enzyme with modified Activity. J. Mol. Biol. 366, 1258-1265 doi: 10.1016/j.jmb.2006.12.016Abstract


Lizano-Gonzales, E. and Mörl, M. (2006) tRNA. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Eds. Ganten, D., Ruckpaul, K., 1920-1924



Mörl, M., Lizano, E., Willkomm, D. K. and Hartmann, R. K. (2005) Production of RNAs with homogeneous 5’- and 3’-Ends. In: Handbook of RNA Biochemistry, Wiley-VCH, Eds. R. K. Hartmann, A. Bindereif, A. Schön, E. Westhof, Wiley-VCH, 22-35


Schuster, J., Betat, H. and Mörl, M. (2005) Is Yeast on its Way to evolving tRNA Editing? EMBO Reports 6, No. 4, 367-372. Corrigendum: EMBO Reports 6, No. 5, 487 doi: 10.1038/sj.embor.7400381Abstract


Hartmann, R. K., Mörl, M. and Sprinzl, M. (2004) The tRNA World. RNA 10, No.3, 344-349


Levinger, L., Oestreich, I., Florentz, C. and Mörl, M. (2004) A Pathogenesis-associated Mutation in human mitochondrial tRNALeu(UUR) leads to Reduced 3'-End Processing and CCA Addition. J. Mol. Biol. 337, No.3, 535-544 doi: 10.1016/j.jmb.2004.02.008Abstract
Schuster, J. and Mörl, M. (2004) Mitochondrial tRNA Editing. Top. Curr. Genet. 8, 81-96
Betat, H., Rammelt, C., Martin, G. and Mörl, M. (2004) Exchange of Regions between bacterial Poly(A) Polymerase and CCA adding Enzyme generates altered Specificities. Mol. Cell 15, 389-398 doi: 10.1016/j.molcel.2004.06.026Abstract
Levinger, L., Mörl, M. and Florentz, C. (2004) Mitochondrial tRNA 3’ end metabolism and human disease. Nucleic Acids Res. 32, No.18, 5430-5441 doi: 10.1093/nar/gkh884Abstract


Betat, H. and Mörl, M. (2003) tRNA Import in Mitochondrien. Biospektrum 1/2003, 33-35
Augustin, M., Reichert, A. S., Betat, H., Huber, R., Mörl, M. and Steegborn, C. (2003) Crystal Structure of the human CCA-adding Enzyme: Insights into Template independent Polymerisation. J. Mol. Biol. 328, No.5, 985-994 Abstract


Schürer, H., Lang, K., Schuster, J. and Mörl, M. (2002) A universal Method to produce in vitro Transcripts with homogenous 3’- Ends. Nucleic Acids Res. 30, e56



Mörl, M. and Marchfelder, A. (2001) The Final Cut: The Importance of tRNA 3’ Processing. EMBO Rep. 2, No.1, 17-20 doi: 10.1093/embo-reports/kve006


Schürer, H., Schiffer, S., Marchfelder, A. and Mörl, M. (2001) This is the End: Reactions at the tRNA 3’- Terminus. Biol. Chem. 382, 1147-1156. doi: 10.1515/BC.2001.144Abstract
Dörner, M., Altmann, M., Pääbo, S. and Mörl, M. (2001) Evidence for import of a lysyl-tRNA into marsupial mitochondria. Mol. Biol. Cell. 12, 2688-2698 Abstract
Reichert, A.S., Thurlow, D.L. and Mörl, M. (2001) A eubacterial Origin for the human tRNA Nucleotidyltransferase? Biol. Chem. 382, 1431-1438 doi: 10.1515/BC.2001.176Abstract


Reichert, A.S. and Mörl, M. (2000) Repair of tRNAs in metazoan Mitochondria. Nucleic Acids Res. 28, No.10, 2043-2048



Reichert, A., Rothbauer, U. and Mörl, M. (1998) Processing and Editing of overlapping tRNAs in human Mitochondria. J. Biol. Chem. 273, 31977-31984



Börner, G.V., Yokobori, S.-i., Mörl, M., Dörner, M. and Pääbo, S. (1997) RNA editing in metazoan Mitochondria: Staying fit without Sex. FEBS Lett. 409, 320-324



Börner, G.V., Mörl, M., Janke, A. and Pääbo, S. (1996) RNA Editing changes the Identity of a mitochondrial tRNA in Marsupials. EMBO J. 15, 5949-5957



Börner, G.V., Mörl, M., Wissinger, B., Brennicke, A. and Schmelzer, C. (1995) RNA Editing of a Group II Intron in Oenothera as a Prerequisite for Splicing. Mol. Gen. Genet. 246, 739-744


Mörl, M., Dörner, M. and Pääbo, S. (1995) C to U Editing and Modifications during the Maturation of the mitochondrial tRNAAsp in Marsupials. Nucleic Acids Res. 23, No.17, 3380-3384 Abstract


Mörl, M., Dörner, M. and Pääbo, S. (1994) Direct Purification of tRNAs Using Oligonucleotides Coupled to Magnetic Beads. Advances in Biomagnetic Separation, Eaton Publishing, Eds. M. Uhlén, E. Hornes, Ø. Olsvik, 107-111



Mörl, M. and Schmelzer, C. (1993) A Simple Method for Isolation of Intact RNA from dried Polyacrylamide Gels. Nucleic Acids Res. 21, No.8, 2016



Mörl, M., Niemer, I. and Schmelzer, C. (1992) New Reactions Catalyzed by a Group II Intron Ribozyme with RNA and DNA Substrates. Cell 70, 803-810



Wallasch, C., Mörl, M., Niemer, I. and Schmelzer, C. (1991) Structural Requirements for Selection of 5'- and 3'- Splice Sites of Group II Introns. Nucleic Acids Res. 19, No.12, 3307-3314



Mörl, M. and Schmelzer, C. (1990) Integration of Group II Intron bI1 into a Foreign RNA by Reversal of the Self-Splicing Reaction In Vitro. Cell 60, 629-636


Schmidt, U., Riederer, B., Mörl, M., Schmelzer, C., and Stahl, U. (1990) Self-Splicing of the Mobile Group II Intron of the Filamentous Fungus Podospora anserina (COI I1) In Vitro. EMBO J. 9, No.7, 2289-2298 Abstract
Mörl, M. and Schmelzer, C. (1990) Group II Intron RNA-Catalyzed Recombination of RNA In Vitro. Nucleic Acids Res. 18, No. 22, 6545-6551 Abstract
letzte Änderung: 13.01.2022