Biophysikalische Chemie

Mission

Synthetic and naturally derived polymer matrices are used to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation and transport.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies to reduce animal experiments.


In a second research area we apply bio-/polymer materials to develop biosensors for the detection of anthropogenic analytes in aqueous environments. The technologies are based on specific receptor-ligand interactions of functionalized hydrogel microparticles and nanoparticles.

letzte Änderung: 12.08.2019

Kontakt

Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939
E-Mail

Sekretariat
Susanne Vogt
Raum 1.36

Telefon: +49 341 97-36780
Telefax: +49 341 97-36939
E-Mail

News

New Paper on Hormone Biosensor

26.07.2021

Together with collaborators we published a paper in Biosensors & Bioelectronics. Using our established soft colloidal probe principle we developed a...

New Paper on 3D brain extracellular matrix model

20.07.2021

We recently published together with collaborators a paper in European Journal of Neuroscience. We introduce a fibrillar 3D matrix as model of the...

New Paper on Using Particle Image Velocimetry to Analyse Fibroblast Differentiation in vitro

09.07.2021

We recently published a paper in Biomaterials Science. We show that we can use the principle of particle image velocimetry to analyze fibroblast...